Cholesterol-tuned liposomal membrane rigidity directs tumor penetration and anti-tumor effect
نویسندگان
چکیده
منابع مشابه
Electrochemotherapy: variable anti-tumor effect on different tumor models
Electrochemotherapy is a new approach in the treatment of tumors that takes advantage of the permeabilization of the cell membrane by electric pulses to facilitate the delivery of chemotherapeutic drugs into the cells, According to the procedures described previously, the anti-tumor effectiveness of electrochemotherapy with bleomycin (BLM) was tested on three different murine tumor models, with...
متن کاملEffect of Skin Tumor Properties on Laser Penetration
Computer modeling can be a valuable tool to determine the absorption of laser light in different skin layers. For this study, the optical properties of three different skin tumors were used in the model to evaluate the effect on penetration depth into the skin. Comparison between the healthy dermis and the skin tumors indicated that up to 28 % more laser light is absorbed in the healthy dermis ...
متن کاملSuppression of membrane microvesiculation--a possible anticoagulant and anti-tumor progression effect of heparin.
Heparins (unfractionated and low molecular weight (LMWH) heparins) primarily used as anticoagulants, were found to be effective also in slowing down the development of some types of cancer. On the other hand, the number of microvesicles in the peripheral blood originating from the budding of cell membranes (mostly platelets) is increased in hypercoagulabile states as well as in cancer, indicati...
متن کاملTumor targeting using liposomal antineoplastic drugs
During the last years, liposomes (microparticulate phospholipid vesicles) have been used with growing success as pharmaceutical carriers for antineoplastic drugs. Fields of application include lipid-based formulations to enhance the solubility of poorly soluble antitumor drugs, the use of pegylated liposomes for passive targeting of solid tumors as well as vector-conjugated liposomal carriers f...
متن کاملVascular damage and anti-angiogenic effects of tumor vessel-targeted liposomal chemotherapy.
The poor selective toxicity of chemotherapeutic anticancer drugs leads to dose-limiting side effects that compromise clinical outcome. Solid tumors recruit new blood vessels to support tumor growth, and unique epitopes expressed on tumor endothelial cells can function as targets for the anti-angiogenic therapy of cancer. An NGR peptide that targets aminopeptidase N, a marker of angiogenic endot...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Pharmaceutica Sinica B
سال: 2019
ISSN: 2211-3835
DOI: 10.1016/j.apsb.2019.02.010